Spielname	Konsole	Release
Samurai Shodown	Mega CD	1995
SEGA Classics Arcade Collection -Limited Edition-	Mega CD	1992
Sensible Soccer	Mega CD	1994
Sewer Shark	Mega CD	1993
Sherlock Holmes: Consulting Detective	Mega CD	1993
Sherlock Holmes: Consulting Detective Vol. II	Mega CD	1994
Shining Force CD	Mega CD	März 1995
Silpheed	Mega CD	1993
Slam City with Scottie Pippen	Mega CD	1994
Snatcher	Mega CD	1994
The Software Toolworks' Star Wars Chess	Mega CD	1994
Sol-Feace	Mega CD	1992
Sonic CD	Mega CD	Oktober 1993
SoulStar	Mega CD	1994
The Space Adventure	Mega CD	1995
Star Wars: Rebel Assault	Mega CD	1994
StarBlade	Mega CD	1994
Supreme Warrior	Mega CD	1994
Surgical Strike	Mega CD	1995
Syndicate	Mega CD	1995