Spielname	Konsole	Release
Star Control	Mega Drive	1991
Starflight	Mega Drive	1991
The Story of Thor	Mega Drive	März 1995
Street Fighter II': Special Champion Edition	Mega Drive	Oktober 1993
Street Racer	Mega Drive	1995
Streets of Rage	Mega Drive	1991
Streets of Rage 3	Mega Drive	1994
Streets of Rage II	Mega Drive	1993
Strider	Mega Drive	1990
Strider 2	Mega Drive	1993
Striker	Mega Drive	1993
Sub-Terrania	Mega Drive	Mai 1994
Sunset Riders	Mega Drive	1992
Super Fantasy Zone	Mega Drive	1993
Super Hang-On	Mega Drive	1989
Super Hydlide	Mega Drive	1991
Super Monaco GP	Mega Drive	1990
Super Skidmarks	Mega Drive	1995
Super Smash T.V.	Mega Drive	1992
Super Street Fighter II	Mega Drive	1994
Super Thunder Blade	Mega Drive	1989
Superman The Man of Steel	Mega Drive	1993
Sword of Sodan	Mega Drive	1990
Sword of Vermillion	Mega Drive	1990
Syndicate	Mega Drive	1990